iMer protects against thrombus formation without increasing bleeding in preliminary studies. (A) C57BL/6 mice were injected with collagen/epinephrine to induce systemic venous thrombosis resulting in pulmonary embolism. WT mice treated with 60 mg/kg iMer (red, n = 9) and Gas6^−/− KO mice (blue, n = 6) exhibited a significant increase in survival compared with vehicle-treated controls (green line; n = 7; ∗∗P < .01 by log-rank [Mantel-Cox] test). (B) Tail-clip bleeding times did not differ significantly among WT mice treated with 60 mg/kg iMer (red, n = 3) or vehicle control (green, n = 8), or Gas6^−/− KO mice (blue, n = 5; ∗∗P < .01 by log-rank [Mantel-Cox] test). KO, knockout; WT, wild-type.