Figure 2.
Depletion of ribosome processing factors in human NPM1c+ AML. (A) Volcano plot of protein abundance in bone marrow samples from NPM1c+ (n = 8) vs NPM1wt (n = 36) human de novo AMLs.22 (B-I) Relative protein (B-E) or RNA abundance (F-I) of selected ribosome-related candidates in NPM1c+ (n = 8) vs NPM1wt (n = 36) AML patients (mean ± SD). Panel A, unpaired t test with multiple-hypothesis–testing correction (FDR, Benjamini-Hochberg method). (B-I) Unpaired t test was used to calculate P values between groups. ∗P ≤ .05; ∗∗P ≤ .01; ∗∗∗∗P ≤ .0001. ns, nonsignificant. Data available in Kramer et al.22

Depletion of ribosome processing factors in human NPM1c+ AML. (A) Volcano plot of protein abundance in bone marrow samples from NPM1c+ (n = 8) vs NPM1wt (n = 36) human de novo AMLs.22 (B-I) Relative protein (B-E) or RNA abundance (F-I) of selected ribosome-related candidates in NPM1c+ (n = 8) vs NPM1wt (n = 36) AML patients (mean ± SD). Panel A, unpaired t test with multiple-hypothesis–testing correction (FDR, Benjamini-Hochberg method). (B-I) Unpaired t test was used to calculate P values between groups. ∗P ≤ .05; ∗∗P ≤ .01; ∗∗∗∗P ≤ .0001. ns, nonsignificant. Data available in Kramer et al.22 

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