Comutation pattern and survival analysis of SRSF2-mutated cases. (A) Frequencies of comutations in SRSF2-mutated CCUS (gray), MDS (blue) and AML (red). Comutations occurring in at least 2 patients are shown. (B) OS of MDS patients with SRSF2 mutations (mut, n = 102, red; median OS, 2.8 years) vs wildtype SRSF2 (wt, n = 596, gray; median OS, 5.6 years). (C) OS of patients with SRSF2-mutated MDS with ≥3 comutations (n = 51, red; median OS, 1.7 years) vs <3 comutations (n = 51, gray; median OS, 4.4 years).