Impact of residual lesions in patients undergoing tandem ASCT. For 150 patients who underwent tandem ASCT, combined imaging data (PET and DWI) were analyzed after the first and second ASCTs. Patients were stratified based on the presence or absence of FLs at these 2 time points. (A) PFS and (B) OS are presented using a landmark analysis starting from the first ASCT. Group comparisons were performed using the log-rank test. (C-D) The prognostic impact of combined MRD and imaging is shown. PFS from the first (C) or second (D) ASCT is shown, with patients stratified by the combination of MRD status determined by flow cytometry, and the presence or absence of residual FLs detected by imaging (PET and DWI combined). The log-rank test was used to calculate P values.