Functional profiling of SARS-CoV-2 variants of concern spike antibody responses. (A-G) Box plots of B.1.17 S–, B.1.351 S–, and B.1.617 S–specific IgG1, IgG3, IgM, IgA, FcR2A, FcR2B, FcR3A, or FcR3B titers in log10 MFI. Lines represent the minimum, lower quartile, median, upper quartile, and maximum. Statistical significance between groups was tested with a nonparametric Kruskal-Wallis multiple comparisons test. P values are as indicated. (H-J) Truncated violin plots of B.1.17 S–, B.1.351 S–, and P.1 S–directed ADNP. The dashed lines represent quartiles, with a solid black line denoting the median. Statistical significance between groups was tested with a nonparametric Kruskal-Wallis multiple comparisons test. P values are indicated as follows: ns, P = .1234; ∗P = .0332; ∗∗P = .0021; ∗∗∗P = .0002; ∗∗∗∗P < .0001. (K-M) Truncated violin plots of B.1.17 S–, B.1.351 S–, and P.1 S–directed ADCP. The dashed lines represent quartiles, with a solid black line denoting the median. Statistical significance between groups was tested with a nonparametric Kruskal-Wallis multiple comparisons test. P values are indicated as follows: ns, P = .1234; ∗P = .0332; ∗∗P = .0021; ∗∗∗P = .0002; ∗∗∗∗P < .0001.