Skeletal muscle microvasculature in SCD and relationship with clinical features. (A) Comparison of skeletal muscle capillary density between genotype. (B-C). Relationship between capillary density and both circulating sL-selectin (B) and ICAM (C) levels. (D) Comparison of skeletal muscle COD between genotype. (E-F) Relationship between COD and both the MCHCS in erythrocytes (E) and plasmatic concentration of VEGF (F). Genotype effects were obtained with 1-way analysis of variances (ANOVA) analysis. Post hoc analysis: ^a,b,cConditions not sharing the same letter were significantly different (P < .05). MCHCS, mean corpuscular HbS concentration.