Skeletal muscle remodeling and factors of oxidative status regulation for CONs, carriers of SCT, and patients with SCD. (A) Circulating level of AOPPs. (B) mRNA expression of antioxidant-related gene. (C-F) Analysis of myocytes characteristics on muscle cryosections based on immunohistological analysis. Values are mean (standard deviation). Light gray bar, females; dark gray bar, males. The effects of genotype ∗ sex and sex were obtained with 2-way ANOVA analysis. Box-Cox transformation has been performed before analysis for panels E-F. Post hoc analysis: ^a,b,c,dconditions not sharing the same letter were significantly different (P < .05). SCA, sickle cell anemia.