Ablation laser-injury models of thrombus formation. (A) In vivo laser-injury model performed by exteriorizing the mesenteric vein, or artery, and pulsing a high-powered laser. Representative image of platelet (CD42b, green) and fibrin (magenta) accumulation on mesenteric vein endothelium (CD31, red). (B) In vitro laser-injury model performed by pulsing a high-powered laser on the endothelialized surface of a microfluidic chip (Endo-chip). Representative image of platelet (CD41, green), fibrin (magenta), and annexin V (red).