Spatial molecular and cellular map of PCs. (A) UMAP plot of the combined data set of PCs from controls (n = 4), MGUS/SM (n = 7), and MM (n = 10). Colors represent PC clusters. (B) UMAP plot of panel A split into controls, MGUS/SM, and MM data sets. (C) Proportion of PC clusters in each sample. (D) Dot plot showing differentially expressed genes between PC populations in panel A. (E) UMAP and spatial plots for representative control (Ctrl-3), MGUS (MGUS-1 and MGUS-2), SM (SM-1 and SM-5), and all MM (MM-1 to MM-10) samples. Scale bars, 1 mm.