Spatially resolved neighborhood analysis of stromal cells. (A) UMAP plot of the combined data set of stromal cells from controls (n = 4), MGUS/SM (n = 7), and MM (n = 10). (B) Dot plot showing differentially expressed genes between stromal cell populations in panel A. (C) UMAP plot of panel A split into controls, MGUS/SM, and MM data sets. (D) Proportion of stromal cell clusters in each sample. (E) UMAP and spatial plots for representative control (Ctrl-3), MGUS (MGUS-1 and MGUS-2), SM (SM-1 and SM-5), and all MM (MM-1 to MM-10) samples. Scale bars, 1 mm. AEC, arterial endothelial cell; SEC, sinusoidal endothelial cell; VSMC, vascular smooth muscle cells.