Dual inhibition of G9a and DNMTs promotes expression of TSGs in MM cells. (A-C) RNA-seq data of significantly (adjusted P < .05; log2 0.5-fold) downregulated and upregulated genes as a result of dual G9a and DNMTs inhibition in the MM cell lines KMS-28, INA-6, and OPM2. Statistical test: Wald test with Benjamini-Hochberg procedure to control the FDR. (D-F) Venn diagram showing genes that gain expression in samples treated with the combination therapy. (G-I) Significantly upregulated (adjusted P < .05; log2 0.5-fold) TSGs in samples treated with the combination therapy. FC, fold change; TPM, transcript per million.
Figure 5.

Dual inhibition of G9a and DNMTs promotes expression of TSGs in MM cells. (A-C) RNA-seq data of significantly (adjusted P < .05; log2 0.5-fold) downregulated and upregulated genes as a result of dual G9a and DNMTs inhibition in the MM cell lines KMS-28, INA-6, and OPM2. Statistical test: Wald test with Benjamini-Hochberg procedure to control the FDR. (D-F) Venn diagram showing genes that gain expression in samples treated with the combination therapy. (G-I) Significantly upregulated (adjusted P < .05; log2 0.5-fold) TSGs in samples treated with the combination therapy. FC, fold change; TPM, transcript per million.

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