Alterations in Trp metabolome in mice with syngeneic colon cancer tumors. (A) Average diet intake in grams was measured in 4 age-matched female mice subjected to different Trp diets over 4 days. The y-axis denotes the diet intake per day per mouse. Error bars represent SEM. (B-E) Average levels of Trp metabolites in 4 to 5 mice per group are shown. Error bars represent SEM. ANOVA was performed to compare all the groups. P = .0006 (Trp levels ANOVA); P = .0017 (Kyn ANOVA); P = .0147 (kynurenic acid ANOVA); indoxyl sulfate ANOVA was not significant. Student t test was performed to compare individual groups. For kynurenic acid, in the nontumor group, P = .0631 (between normal and high Trp groups); P = .0778 (between zero and high Trp groups). No significant differences were noted between different diets in the tumor groups. (F) A linear correlation of normalized clot weights with Kyn levels.
Figure 5.

Alterations in Trp metabolome in mice with syngeneic colon cancer tumors. (A) Average diet intake in grams was measured in 4 age-matched female mice subjected to different Trp diets over 4 days. The y-axis denotes the diet intake per day per mouse. Error bars represent SEM. (B-E) Average levels of Trp metabolites in 4 to 5 mice per group are shown. Error bars represent SEM. ANOVA was performed to compare all the groups. P = .0006 (Trp levels ANOVA); P = .0017 (Kyn ANOVA); P = .0147 (kynurenic acid ANOVA); indoxyl sulfate ANOVA was not significant. Student t test was performed to compare individual groups. For kynurenic acid, in the nontumor group, P = .0631 (between normal and high Trp groups); P = .0778 (between zero and high Trp groups). No significant differences were noted between different diets in the tumor groups. (F) A linear correlation of normalized clot weights with Kyn levels.

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