IDO1 inhibition alters TF, PAI-1, and TM expression in IVC of mice with tumors exposed to a high Trp diet. (A) Representative images of tissue sections of IVC from MC38 tumor–bearing mice stained with TF and CD31. DAPI was used for nuclear stain (scale bar, 100 μm). White arrowheads point to the TF expression on endothelial cells, and asterisk points to the subendothelial cells (B) Averages of normalized ID are shown. ANOVA (P < .0001). Student t test was used to compare groups. (C) Representative images of tissue sections of IVC from mice in different groups stained with PAI-1 and CD31. DAPI was used for nuclear stain (scale bar, 100 μm). White arrowheads point to the PAI-1 expression on endothelial cells, and asterisk points to the subendothelial cells. (D) Averages of normalized ID are shown. ANOVA (P = .0036). Student t test was used to compare groups. (E) Representative images of tissue sections of IVC from MC38 tumor–bearing mice stained with TM and CD31. DAPI was used for nuclear stain (scale bar, 100 μm). (F) Averages of normalized ID are shown. Data are representative of 5 age-matched female mice per group. ANOVA (P = .0015). Student t test was used to compare groups. ns, nonsignificant.
Figure 7.

IDO1 inhibition alters TF, PAI-1, and TM expression in IVC of mice with tumors exposed to a high Trp diet. (A) Representative images of tissue sections of IVC from MC38 tumor–bearing mice stained with TF and CD31. DAPI was used for nuclear stain (scale bar, 100 μm). White arrowheads point to the TF expression on endothelial cells, and asterisk points to the subendothelial cells (B) Averages of normalized ID are shown. ANOVA (P < .0001). Student t test was used to compare groups. (C) Representative images of tissue sections of IVC from mice in different groups stained with PAI-1 and CD31. DAPI was used for nuclear stain (scale bar, 100 μm). White arrowheads point to the PAI-1 expression on endothelial cells, and asterisk points to the subendothelial cells. (D) Averages of normalized ID are shown. ANOVA (P = .0036). Student t test was used to compare groups. (E) Representative images of tissue sections of IVC from MC38 tumor–bearing mice stained with TM and CD31. DAPI was used for nuclear stain (scale bar, 100 μm). (F) Averages of normalized ID are shown. Data are representative of 5 age-matched female mice per group. ANOVA (P = .0015). Student t test was used to compare groups. ns, nonsignificant.

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