Residual effect of andexanet alfa on thrombin generation in the absence of DOAC. Assessment of TG was performed in NPP in the presence of 1 to 128 nM andexanet alfa (trigger 1 pM TF). Shown are representative traces (A) and the parameters lag time (B), thrombin peak level (C), time to peak (D), and velocity index (E). Means ± SD (n = 3). ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001 (ANOVA).