Effect of anti-TPFI antibodies on subject-dependent thrombin generation with andexanet alfa. Assessment of TG in plasmas from 20 healthy subjects in the presence of 200 nM blocking anti-TFPI mAb and 200 nM andexanet alfa (trigger 1 pM TF). Shown are the trace parameters lag time (A), thrombin peak level (B), velocity index (C), and time to peak (D); medians (n = 20). ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, and ∗∗∗∗P < .0001.
Figure 3.

Effect of anti-TPFI antibodies on subject-dependent thrombin generation with andexanet alfa. Assessment of TG in plasmas from 20 healthy subjects in the presence of 200 nM blocking anti-TFPI mAb and 200 nM andexanet alfa (trigger 1 pM TF). Shown are the trace parameters lag time (A), thrombin peak level (B), velocity index (C), and time to peak (D); medians (n = 20). ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, and ∗∗∗∗P < .0001.

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