Figure 4.
Effect of heparin on thrombin generation with andexanet alfa. Assessment of TG in NPP in the presence of 0.05 U/mL heparin (UFH) and 128 nM andexanet alfa (trigger 1 pM TF). Shown are representative traces (A), and the parameters lag time (B), thrombin peak (C), time to peak (D), and velocity index (E). Means ± SD (n = 3). ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001 (ANOVA).