Effect of pentasaccharide on thrombin generation with andexanet alfa. Assessment of TG in NPP in the presence of 250 nM pentasaccharide, 250 nM anti-TFPI mAb, and/or 500 nM andexanet alfa, as indicated (trigger: 1 pM TF). Shown are representative traces (A) and the parameters lag time (B) and thrombin peak (C). Means ± SD (n = 3). ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001 (ANOVA).
Figure 5.

Effect of pentasaccharide on thrombin generation with andexanet alfa. Assessment of TG in NPP in the presence of 250 nM pentasaccharide, 250 nM anti-TFPI mAb, and/or 500 nM andexanet alfa, as indicated (trigger: 1 pM TF). Shown are representative traces (A) and the parameters lag time (B) and thrombin peak (C). Means ± SD (n = 3). ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001 (ANOVA).

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