Reversal by andexanet alfa of endothelial suppression of thrombin generation. Assessment of TG in control wells (A-C) or HUVEC-grown wells (D-F) using whole-blood supplemented with 250 nM anti-TFPI mAb and/or 150 nM andexanet alfa (trigger: 0.1 pM TF). Shown are representative traces (A,D) and the parameters lag time (B,E), and thrombin peak level (C,F). Means ± SD (n = 3). ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001 (ANOVA).
Figure 6.

Reversal by andexanet alfa of endothelial suppression of thrombin generation. Assessment of TG in control wells (A-C) or HUVEC-grown wells (D-F) using whole-blood supplemented with 250 nM anti-TFPI mAb and/or 150 nM andexanet alfa (trigger: 0.1 pM TF). Shown are representative traces (A,D) and the parameters lag time (B,E), and thrombin peak level (C,F). Means ± SD (n = 3). ∗P < .05, ∗∗P < .01, and ∗∗∗P < .001 (ANOVA).

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal