Mechanism of action of RGI-2001. RGI-2001 is a glycolipid presented through the CD1d molecule of APCs and thereby selectively activates iNKT cells. The iNKT cells produce cytokines resulting in proliferation and expansion of Tregs. Tregs suppress alloreactive T cells and produce anti-inflammatory cytokines abrogating the onset of aGVHD.

Mechanism of action of RGI-2001. RGI-2001 is a glycolipid presented through the CD1d molecule of APCs and thereby selectively activates iNKT cells. The iNKT cells produce cytokines resulting in proliferation and expansion of Tregs. Tregs suppress alloreactive T cells and produce anti-inflammatory cytokines abrogating the onset of aGVHD.

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