Differential enhancer regions in KMT2A::AFF1 patients are readily observed. (A) UMAP of the single-cell ATAC-seq modality for 4 KMT2A::AFF1 blast samples from the VIVO Biobank, United Kingdom. (B) Regions of accessible chromatin displaying significantly increased accessibility in 1 of 4 patient samples. (C) Genomic distribution of uniquely accessible ATAC-seq peaks relative to the nearest TSS, the dotted gray line indicates 2.5 kb. (D) Annotation of the genomic location of unique ATAC-seq peaks. (E) Schematic of the strategy used to identify unique enhancer peaks using H3K27ac ChIP-seq data sets. (F) Tornado plot of H3K27ac signal in KMT2A::AFF1 samples at enhancers identified as being patient specific. UMAP, uniform manifold approximation and projection.
Figure 4.

Differential enhancer regions in KMT2A::AFF1 patients are readily observed. (A) UMAP of the single-cell ATAC-seq modality for 4 KMT2A::AFF1 blast samples from the VIVO Biobank, United Kingdom. (B) Regions of accessible chromatin displaying significantly increased accessibility in 1 of 4 patient samples. (C) Genomic distribution of uniquely accessible ATAC-seq peaks relative to the nearest TSS, the dotted gray line indicates 2.5 kb. (D) Annotation of the genomic location of unique ATAC-seq peaks. (E) Schematic of the strategy used to identify unique enhancer peaks using H3K27ac ChIP-seq data sets. (F) Tornado plot of H3K27ac signal in KMT2A::AFF1 samples at enhancers identified as being patient specific. UMAP, uniform manifold approximation and projection.

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