Mutational background of NUP98r leukemia associated with disease phenotypes. (A) Genetic profiles of NUP98r samples in the cohort. Colors indicate patient annotations (top) and types of gene alterations (bottom). (B) Co-occurrence and mutual exclusivity among recurrent alterations (n ≥ 3). (C) Enrichment of somatic alterations in transcriptional clusters (left) and fusion partners (right). In panels B-C, colors indicate adjusted P values by 2-sided Fisher’s exact tests and the Benjamini-Hochberg adjustment (red: co-occurring, blue: mutually exclusive), and asterisks indicate statistically significant values (adjusted P values, ∗P < .05; ∗∗P < .01; ∗∗∗P < .001). Annotations of genes in mutational heat maps depend on known general functions.
Figure 2.

Mutational background of NUP98r leukemia associated with disease phenotypes. (A) Genetic profiles of NUP98r samples in the cohort. Colors indicate patient annotations (top) and types of gene alterations (bottom). (B) Co-occurrence and mutual exclusivity among recurrent alterations (n ≥ 3). (C) Enrichment of somatic alterations in transcriptional clusters (left) and fusion partners (right). In panels B-C, colors indicate adjusted P values by 2-sided Fisher’s exact tests and the Benjamini-Hochberg adjustment (red: co-occurring, blue: mutually exclusive), and asterisks indicate statistically significant values (adjusted P values, ∗P < .05; ∗∗P < .01; ∗∗∗P < .001). Annotations of genes in mutational heat maps depend on known general functions.

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