Increased expressions of T-cell activation markers at time of screening were associated with improved PFS in patients treated with SEL-based regimens. (A) Forest plot of PFS HRs for the expression of indicated markers on CD3+ T cells from screening samples. HRs are not corrected for multiple testing. Kaplan-Meier curves show PFS stratified by CD3+ T-cell expression of CD45 (B), STING (C), MET (D), and phosphorylated p90 RSK T359/S363 (E). MET, MET proto-oncogene, receptor tyrosine kinase; phospho p90 RSK, phosphorylated p90 ribosomal protein S6 kinase A1; STING, stimulator of interferon response CGAMP interactor 1.
Figure 3.

Increased expressions of T-cell activation markers at time of screening were associated with improved PFS in patients treated with SEL-based regimens. (A) Forest plot of PFS HRs for the expression of indicated markers on CD3+ T cells from screening samples. HRs are not corrected for multiple testing. Kaplan-Meier curves show PFS stratified by CD3+ T-cell expression of CD45 (B), STING (C), MET (D), and phosphorylated p90 RSK T359/S363 (E). MET, MET proto-oncogene, receptor tyrosine kinase; phospho p90 RSK, phosphorylated p90 ribosomal protein S6 kinase A1; STING, stimulator of interferon response CGAMP interactor 1.

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