Multiomics analyses reveal distinct molecular signatures depended on VTE status. (A) The cohort comprised 145 patients, including 121 who did not develop VTE (green) and 24 who developed VTE (purple). Blood samples were collected from each patient at 8 time points, spanning from arrival to 8 days after admission. The plasma fraction of these samples was subjected to MS-based multiomics analyses. (B) LDA was performed on the metabolomic and proteomic profiles of the patients across the monitored time points. (C) Protein network detected by the LDA model, annotated with the top significantly enriched biological processes, highlighting the functional implications of the proteomic alterations.