Genetic morphologic associations in MDS. (A) Dysplastic features evaluated include (clockwise from top left) erythroid binucleation, erythroid nuclear irregularity, erythroid karyorrhexis, erythroid mitosis, ring sideroblast, Auer rod, abnormal myeloid nuclear segmentation, myeloid hypogranulation, hypolobated megakaryocyte, and separated megakaryocyte nuclei. (B) Correlation matrix showing association between evaluated dysplastic features and gene mutations in the discovery cohort. Only associations with adjusted P value < .05 are shown. The area of each circle represents the absolute Spearman correlation coefficient (ρ). Mk, megakaryocytes; N, number of samples; N:C, nuclear-to-cytoplasmic.