The genetic landscape of HGBCL-NOS. (A) The architecture of MYC rearrangements and the observed frequency of IGH, IGK, IGL, and non-IG rearrangement partners. The outermost ring shows the chromosome ideogram, followed by a genomic coordinate scale and gene coordinate track. The innermost lines show the linkages between MYC and the corresponding rearrangement partner for each sample. (B) The architecture of IGH::MYC rearrangements and the frequency of breakpoints occurring at the indicated regions of the IGH locus. Eμ and 3′ regulatory region enhancers are included in the gene coordinate track (red). (C) Copy number profile of HGBCL-NOS. The proportion of tumors with a copy number gain (red) or deletion (blue) is plotted across each chromosome. (D) Oncoplot showing the mutation status of the most frequently mutated genes in HGBCL-NOS for each patient tumor. Genes included in the plot were mutated in at least 10% of HGBCL-NOS samples and identified as a significantly mutated gene in HGBCL-NOS, DLBCL-NOS, or BL. (E) PCA of RNA sequencing data. COMP, composite; NA, not available.