Overall survival (OS). (A) All randomized patients. (B) Patients with ≥1 high prognostic risk factor including mutated TP53, uIGHV, del(11q), and/or CK. (C) Patients with uIGHV or mIGHV. (D) Patients with or without del(11q). CK, complex karyotype; Clb, chlorambucil; mIGHV, mutated immunoglobulin heavy chain variable; PD, progressive disease; uIGHV, unmutated immunoglobulin heavy chain variable.
Figure 3.

Overall survival (OS). (A) All randomized patients. (B) Patients with ≥1 high prognostic risk factor including mutated TP53, uIGHV, del(11q), and/or CK. (C) Patients with uIGHV or mIGHV. (D) Patients with or without del(11q). CK, complex karyotype; Clb, chlorambucil; mIGHV, mutated immunoglobulin heavy chain variable; PD, progressive disease; uIGHV, unmutated immunoglobulin heavy chain variable.

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