OS of patients with <5% and ≥5% BM blasts in the molecular classes in which BM blasts significantly affected OS. The only molecular classes in which blast count significantly affected OS were SF3B1, No-event, and EZH2-ASXL1. Within the No-event class, 8 of 12 patients with ≥5% blasts received SCT compared with 3 of 13 patients in the <5% blast group.