Risk factors for ICANS. (A) Incidence and grading of ICANS according to the different prophylactic strategies (with or without LVT). (B) Risk factors for ICANS of any grade in univariate analysis (forest plot). ASCT, autologous hematopoietic stem cell transplantation; CR, complete response; DLBCL, diffuse large B-cell lymphoma; IPI, International Prognostic Index; ECOG, Eastern Cooperative Oncology Group performance status scale; PD, progressive disease; PMBL, primary mediastinal BCL; PR, partial response; SD, stable disease; tFL, transformed follicular lymphoma; tisa-cel, tisagenlecleucel.