Irradiated anatomic site and risk of CH. (A) ORs with 95% confidence intervals for DDR-CH and irradiated anatomic sites in multivariable logistic regression adjusted for age, race, time from diagnosis to blood draw, smoking status, and chemotherapy class. ORs are plotted per 10-Gy dose increments in EQD₂. (B) ORs between irradiated anatomic sites and individual DDR-CH mutations, adjusted via multivariable logistic regression as in panel A. ∗, P < 0.05; ∗∗, P < 0.01.