Enrichment of tissue-resident signatures in EBV-infected NK cells. (A) UMAP embedding of scRNA-seq data for 49 878 cells from PBMCs of 3 patients with CIMP-positive CAEBV, 3 patients with CIMP-negative CAEBV, 2 patients with IM, and 2 healthy volunteers. Twenty-two cell types were defined according to the RNA expression of marker genes (supplemental Figure 8A). (B) UMAP plot colored according to EBER1 expression level. (C) Violin plot showing the expression of EBER1 in each cell type. (D) The expression of NK-lineage-defining surface markers is displayed using violin plots in 3 NK clusters (NK, EBV-infected NK, and CD56^bright NK). (E) UMAP embedding of NK cells colored by CD49⁺ peripheral blood NK (CD49⁺ pbNK) up (upper) and down (lower) gene score. The score was calculated using a published gene list (supplemental Table 12). (F) Representative images of dual immunostaining for EBER (brown) and CD49a (red) in a human stomach biopsy sample (K_C_01, left), a skin lesion biopsy sample (T_H_01, middle), and a liver sample from a PDX mouse engrafted with NK-LCLs (S_C_10, right). cDC, conventional dendritic cell; dnT, double negative T; gdT, γδ T; HSPC, hematopoietic stem and progenitor cell; MAIT, mucosal associated invariant T; pDC, plasmacytoid dendritic cell; PD-L1, programmed cell death 1 ligand 1; PDX, patient-derived xenograft; Treg, regulatory T.