Types and anatomical sites of postsplenectomy thrombotic events among patients with ITP. (A) The bar chart displays the distribution of thrombotic event types among all patients (N = 88) after splenectomy, with venous thrombosis accounting for most events, followed by arterial and combined arterial and venous events. The pie charts detail the anatomical sites involved: DVT and PE were most common among venous events, whereas coronary and cerebral arteries were the leading arterial sites. (B) Thrombotic events are stratified by postsplenectomy TPO-RA use. Venous events remained dominant in both groups; however, combined events occurred exclusively among patients who received TPO-RAs. The corresponding pie charts outline the anatomical distribution for each group. In the TPO-RA group, DVT and PE remained the most frequent, whereas the non–TPO-RA group exhibited a broader distribution of both venous and arterial sites, including cardiac and renal arteries. The multisite VTE observed in the TPO-RA group involved lower-limb DVT, PE, and SVT affecting the portal and mesenteric veins. Isolated splenic vein thrombosis events were not counted as thrombotic events because they are considered postsplenectomy findings and not clinically relevant unless extension beyond the splenic vein occurs. CVT, cerebral venous thrombosis; DVT, deep vein thrombosis; PE, pulmonary embolism; RVT, renal vein thrombosis; SVT, splanchnic vein thrombosis; VTE, venous thromboembolism.