scRNA-seq data in Tabula Sapiens database for the genes of interest. (A) Volcano plot of differentially expressed genes. We compared platelet and megakaryocyte clusters (n = 58 662 cells) with lymphocytes (n = 11 854 143 cells) using Tabula Sapiens differential expression tool (t test). Among 55 512 genes, 34 291 are significantly differentially expressed (adjusted P ≤ .001). We show the genes that are overexpressed in platelets/megakaryocytes in red (positive effect) and the genes that are overexpressed in lymphocytes in blue (negative effect). We show the name of the significantly differentially expressed genes associated with the sentinel and/or the proxies in at least 1 annotation tool used. (B) Expression of each gene of interest in different cell clusters in blood or bone marrow. Genes are organized by locus. We selected clusters with >500 cells, and in which at least one of our genes shows a scaled expression >0.2 in >10% of cells. Color represents the scaled expression, and the size of the dots represents the proportion of expressing cells. We highlighted platelets and megakaryocytes in blue box. We also highlighted with a green circle the clusters in which expression is >2 in at least 500 cells.