scRNA-seq in ITP and HCs. (A) UMAP of the scRNA-seq of the 4 bone marrow samples of patients with ITP. We show the annotation of each cell type. (B) Expression in patients with ITP of 3 genes of the Wnt pathway. Color gradients show the relative expression. (C) Differential expression of the genes of the Wnt pathway between patients with ITP and HCs in all cells (left) or in the cell type they are expressed (right). cDC, conventional dendritic dell; CDP, common dentritic cell progenitor; HSC, hematopoietic stem cell; MEP, megakaryocyte-erythroid progenitor; MHC, major histocompatibility complex; NK, natural killer; pDC, plasmacytoid dendritic cell; UMAP, Uniform manifold approximation and projection.