GlycoCheck parameters in HIs and patients, and correlation with EASIX. (A) Schematic representation of the GlycoCheck sublingual microscope, including the measurement setup, sublingual positioning, and an example image showing RBC flow through capillaries (see also supplemental Video). (B-D) Comparison of HIs and patients with hematological disease (preconditioning) across key GlycoCheck endothelial parameters stratified by VD between 4 and 25 μm. Median values were calculated for each individual and plotted by vessel size; (B) PBR (μm); (C) vascular density (mm/mm2); (D) RBC velocity (μm/s). P values from Wilcoxon rank-sum tests comparing HIs and patients are indicated for each diameter range. (E-F) Spearman ρ correlation coefficients (with 95% CIs) for EASIX and GlycoCheck parameters, calculated by individual VD. (E) Correlation between EASIX and PBR; (F) correlation between EASIX and vascular density; (G) correlation between EASIX and RBC velocity. VD, vessel diameter.
