Figure 4.
Serum cytokines in HIs and patients, and correlation with GlycoCheck and Tivita. (A) Cytokine levels were measured from frozen serum samples using R&D DuoSet ELISA kits. (B) Box plots comparing serum levels of endothelial-associated cytokines between HIs and patients, with Kruskal-Wallis tests used for statistical analysis (P values shown). Markers analyzed include ANG2 (n = 238); CXCL8 (n = 242); CXCL9 (n = 242), IL-18 (n = 239); and sCD141 (n = 242). (C-D) Linear regression analyses of IL-18 with Tivita parameters. (C) Positive correlation with TWI; (D) negative correlation with NIR; (E) Spearman ρ correlation analysis between IL-18 and GlycoCheck PBR. Correlation coefficients (red line) with 95% CIs (gray and black lines) are shown for each VD between 4 and 25 μm. A correlation was considered significant if the entire CI lay on 1 side of the y-axis. ELISA, enzyme-linked immunosorbent assay.

Serum cytokines in HIs and patients, and correlation with GlycoCheck and Tivita. (A) Cytokine levels were measured from frozen serum samples using R&D DuoSet ELISA kits. (B) Box plots comparing serum levels of endothelial-associated cytokines between HIs and patients, with Kruskal-Wallis tests used for statistical analysis (P values shown). Markers analyzed include ANG2 (n = 238); CXCL8 (n = 242); CXCL9 (n = 242), IL-18 (n = 239); and sCD141 (n = 242). (C-D) Linear regression analyses of IL-18 with Tivita parameters. (C) Positive correlation with TWI; (D) negative correlation with NIR; (E) Spearman ρ correlation analysis between IL-18 and GlycoCheck PBR. Correlation coefficients (red line) with 95% CIs (gray and black lines) are shown for each VD between 4 and 25 μm. A correlation was considered significant if the entire CI lay on 1 side of the y-axis. ELISA, enzyme-linked immunosorbent assay.

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