Figure 2.
Cryo-EM structure of the TF/FVIIa/XK1/10H10 complex. (A) Four views of the cryo-EM density map (at contour level of 0.1), together with the model of the TF/FVIIa/XK1/10H10 complex. The less structured portions of the XK1 density map (contour level of 0.04) are shown as a mesh, and the density for the nanodisc and MBP was subtracted for clarity. Views are rotated 90° around the y-axis. FVIIa, orange; TF, purple; XK1, light sea green; and 10H10 Fab, dark blue. (B) Views of the model of TF/FVIIa/XK1 complex, rotated 90° around the y-axis, with the same color scheme as in panel A. For clarity, the 10H10 Fab is not included in these views.