ASCT2 expression is associated with a poor prognosis in MM. Correlation between ASCT2 expression and clinical outcomes in MM in PFS (A) and OS (B). (C) ASCT2 messenger RNA expression levels in NBs, CBs, CCs, MEMs, TPCs, and BMPCs, as well as in MM aspirates and MM cell lines. (D) Proliferation of human MM cell lines in culture medium with decreasing concentrations of Gln. Percentage of proliferation with respect to that found in culture medium supplemented with Gln at 2 mM. (E) ASCT2 expression in CD4⁺ and CD8⁺ T cells in patients who experienced a CR compared with those who did not respond to therapy. Data represent mean ± SEM and were analyzed using 1-way ANOVA with Bonferroni multiple comparisons test (∗P < .05; ∗∗∗P < .001). BMPC, BM plasma cell; CB, centroblast; CCs, centrocytes; CR, complete response; MEM, memory B cells; NB, naïve B cells; NS, no significance; PD, progressive disease; TPC, tonsillar plasma cell; TPM, transcripts per million.