Figure 6. Efficacy of Cpd R in in vivo... | American Society of Hematology

Figure 6.

Efficacy of Cpd R in in vivo MCL model. In the subcutaneous model, Z138 cells (5 × 106) were injected in the flank region (n = 6). Ten days after establishing the tumor, mice were randomized and treated with Cpd R (75 mg/kg IP twice daily) for 14 days. The analysis involved monitoring of (A) tumor growth volume and (B) changes in body weight, which were assessed every 3 days. (C) HE staining and immunohistochemistry staining of Ki67 and PAX5 of tumor sections are analyzed between vehicle and drug-treated animals. Original magnification ×20. HE, hematoxylin and eosin.

Efficacy of Cpd R in in vivo MCL model. In the subcutaneous model, Z138 cells (5 × 10⁶) were injected in the flank region (n = 6). Ten days after establishing the tumor, mice were randomized and treated with Cpd R (75 mg/kg IP twice daily) for 14 days. The analysis involved monitoring of (A) tumor growth volume and (B) changes in body weight, which were assessed every 3 days. (C) HE staining and immunohistochemistry staining of Ki67 and PAX5 of tumor sections are analyzed between vehicle and drug-treated animals. Original magnification ×20. HE, hematoxylin and eosin.

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