mHPX levels in Townes mice transduced with the rAAV8-mHPX vector. (A) mRNA expression of mHPX in liver samples of mice transduced with 1 × 10¹⁴ vg/kg rAAV8-mHPX vector (n = 8 to 13 per group). (B) mHPX levels in mouse plasma before vector infusion (basal), 8 and 28 weeks after infusion with 1 × 10¹⁴ vg/kg rAAV8-mHPX vector (n = 9 to 14 per group). The results are presented as median and mean ± standard error of the mean (SEM) and P values are from the Mann-Whitney U test. AU, arbitrary unit.