Figure 5. Pooled HI-E response rates per... | American Society of Hematology

Figure 5.

$Pooled HI-E response rates per International Working Group (IWG) 2018 criteria in patients with LR-MDS treated with luspatercept. This forest plot depicts HI-E response rates based on the IWG 2018 criteria in patients with TD LR-MDS treated with Lusp. Studies were stratified into 4 clinical subgroups: ESA naïve, RS+; refractory ESA, RS+ with HTB/LTB; refractory ESA, RS+/RS– mixed; and refractory ESA, RS–. Each square represents the HI-E rate from an individual study, with horizontal lines showing 95% CIs; the size of each square reflects the weight of that study in the meta-analysis. Diamonds denote the pooled estimates from fixed-effect and random-effects models for each subgroup and overall. Group 3 is the variable that is used to subgroup the studies that built over the included population of patients in the study, as shown in the figure. Lusp, luspatercept.$

Pooled HI-E response rates per International Working Group (IWG) 2018 criteria in patients with LR-MDS treated with luspatercept. This forest plot depicts HI-E response rates based on the IWG 2018 criteria in patients with TD LR-MDS treated with Lusp. Studies were stratified into 4 clinical subgroups: ESA naïve, RS⁺; refractory ESA, RS⁺ with HTB/LTB; refractory ESA, RS⁺/RS^– mixed; and refractory ESA, RS^–. Each square represents the HI-E rate from an individual study, with horizontal lines showing 95% CIs; the size of each square reflects the weight of that study in the meta-analysis. Diamonds denote the pooled estimates from fixed-effect and random-effects models for each subgroup and overall. Group 3 is the variable that is used to subgroup the studies that built over the included population of patients in the study, as shown in the figure. Lusp, luspatercept.

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