Epitope specificity of antidomain I antibodies in triple-positive antiphospholipid syndrome. Antibodies against domain I of β2-glycoprotein I bind 1 of 2 specific epitopes: MBB2-like epitope 1, comprising a discontinuous conformational epitope including Arg39, or epitope 2, stretching across domain I, but not including Arg39. Crystal structure (PDB: 1C1Z) was visualized with PyMOL molecular graphics system. Figure created with BioRender.com. Urbanus R. (2025) https://BioRender.com/3ub2df7.

Epitope specificity of antidomain I antibodies in triple-positive antiphospholipid syndrome. Antibodies against domain I of β2-glycoprotein I bind 1 of 2 specific epitopes: MBB2-like epitope 1, comprising a discontinuous conformational epitope including Arg39, or epitope 2, stretching across domain I, but not including Arg39. Crystal structure (PDB: 1C1Z) was visualized with PyMOL molecular graphics system. Figure created with BioRender.com. Urbanus R. (2025) https://BioRender.com/3ub2df7.

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