Modulation of miR-223-3p levels in platelets. (A) Levels of miR-223-3p (left) and miR-126-3p (right) expression in platelets 48 hours after MK transfection with a miR-223-3p mimic or a negative control. (B) Levels of miR-223-3p (left) and miR-126-3p (right) expression in platelets 7 days after MK progenitor nucleofection with CRISPR-Cas9 complexes or a negative control. Data are from 5 to 8 independent experiments. ∗P < .05; ∗∗∗∗P < .0001. ns, non-significant.