Key findings of Li et al on the role of STK10 in platelets. Role for STK10 in platelet-mediated biological processes (A) and platelet functions (B) along with signaling pathways that support STK phosphorylation, identification of the STK10 substrate, ILK, and potential mechanisms that support integrin activation (C). Studies were performed with platelet/megakaryocyte–specific deletion of STK10 mice (STK10−/−) and its flox/flox counterpart (STK10+/+). The representative figures shown in panel A are from the authors’ data in the accompanying article. Phosphorylated STK10 and ILK are shown with P in a red circle. ↑, increased; ↓, decreased. GPCR: G protein–coupled receptor; GPVI, glycoprotein VI receptor; PI3K, phosphatidylinositol 3-kinase.

Key findings of Li et al on the role of STK10 in platelets. Role for STK10 in platelet-mediated biological processes (A) and platelet functions (B) along with signaling pathways that support STK phosphorylation, identification of the STK10 substrate, ILK, and potential mechanisms that support integrin activation (C). Studies were performed with platelet/megakaryocyte–specific deletion of STK10 mice (STK10−/−) and its flox/flox counterpart (STK10+/+). The representative figures shown in panel A are from the authors’ data in the accompanying article. Phosphorylated STK10 and ILK are shown with P in a red circle. ↑, increased; ↓, decreased. GPCR: G protein–coupled receptor; GPVI, glycoprotein VI receptor; PI3K, phosphatidylinositol 3-kinase.

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