Platelet counts over time in patients included in (A) safety run-in, (B) study cohort 1, (C) cohort 2, and (D) response rates. (A) The median platelet count from screening through the 24-week treatment period is shown for the 3 patients in safety run-in, (B) 9 patients in cohort 1, (C) and 9 patients in cohort 2. Bars represent IQR. Horizontal lines at platelet counts of 50 × 10⁹/L represent the threshold for response. (D) The bar diagram shows the percentage of patients who met the criteria for the primary (response) and secondary (sustained response) end points.