Troglitazone treatment reduces the T-cell stimulatory ability of DCs. Peripheral blood adhering monocytes cultured with GM-CSF and IL-4 in the presence or absence of troglitazone from the first day of culture were incubated with TLR2L Pam₃Cys, TLR3L Poly(I:C), TLR4L LPS, and TLR7L R848, respectively, 24 hours before harvesting the cells. Generated DC populations were used to stimulate allogeneic T lymphocytes in a standard MLR. 1 × 10⁴ DCs were used. Error bars indicate standard deviation. ^**P = .001; ^*P < .02. ▦ indicates DMSO; ▪, TGZ.