OmniViz correlation view of 285 AML patients. The correlation view displays pairwise correlations between AML patients. The cells in the visualization are colored by Pearson correlation coefficient values, with deeper colors indicating higher positive (red) or negative (blue) correlations. The scale bar indicates maximum positive correlation (red) toward maximum negative correlation (blue). The 16 clusters identified in the cohort of 285 AML patients using 2856 probe sets on the basis of the correlation view are indicated (1 to 16).21 Clinical and molecular data are depicted in the columns along the original diagonal of the correlation view.21 FAB classification and karyotype based on cytogenetics are depicted in the first 2 columns (FAB M0, red; M1, green; M2, purple; M3, orange; M4, yellow; M5, blue; M6 gray; and karyotype: normal, green; inv(16), yellow; t(8;21), purple; t(15;17), orange; 11q23 abnormalities, blue; 7(q) abnormalities, red; +8, pink; complex, black; other, gray). FLT3 ITD and NPM1 mutations are depicted in the same set of columns (red bar, positive; green bar, negative). The expression levels of CD34 (probe set: 209543_s_at) in the 285 AML patients are plotted in the last column (bars are proportional to the level of expression). The percentages of the most common (more than 40%) abnormalities, NPM1 mutations, as well as normal karyotypes (NN) for each cluster are indicated.
