Kaplan-Meier analysis of overall survival in normal karyotype or intermediate-risk AML in subgroups defined by the presence or absence of frameshift mutations in NPM1 and/or internal tandem duplication mutations of FLT3. The panels were modified from Figure 3B of Döhner et al (left), Figure 5A of Schnittger et al (middle), and Figures 4A-B of Verhaak et al (right). The vertical hashmarks in the left and middle panels indicate censored patients. Illustration by Frank Forney.