Novel NPM1 sequence variations in AML patients with normal cytogenetics. Wild-type (WT) sequence and breakpoint positions correspond to GenBank accession number NM_002520. Novel mutation types were named provisionally by numbers. Nucleotide insertions are underlined and boldfaced. The predicted protein is shown for each mutation type; gray columns indicate the positions of the 2 C-terminal tryptophan residues. — indicates information not applicable.