Transplantation of isolated BM VEGFR-2/CD34^+/+ and VEGFR-3/CD34^+/+ cells increased incorporation of EGFP⁺ cells in the newly formed LYVE-1⁺ structures. Bone marrow cells were FACS sorted for isolation of VEGFR-3/VEGFR-2^-/- (A), VEGFR-2/CD34^+/+ (B), or VEGFR-3/CD34^+/+ (C) cells. Isolated cells were transplanted to irradiated mice that had been implanted with FGF-2 pellets in the corneas. The percentages of incorporated cells were counted in 5 random fields (D). Immunohistochemical analysis showing presence of VEGFR-3/CD34^+/+ (E-H), VEGFR-2/CD34^+/+ (I-L), or VEGFR-3/VEGFR-2^-/- (M-P) cells within LYVE-1⁺ structures. Tissue cells nuclei were counterstained with PI (E,I,M). Arrows point to overlapping positive signals. Images were captured with a 40 ×/1.30 NA Plan Neofluar objective lens.