MN1-TEL–expressing mice develop T-lymphoid tumors de novo. (A) Survival analysis. MN1-TEL/Mx1-Cre mice (6 to 8 weeks old) were injected with pI-pC (n = 28) or PBS (n = 26). MN1-TEL^KI/WT (MN1-TEL) or Mx1-Cre^+/WT(Mx1-Cre) mice (n = 10) were also injected with pI-pC as controls. ○ indicates T-lymphoid tumor; •, altered myelopoiesis. (B) T-lymphoid tumors in MN1-TEL–expressing mice. (Left panel) Typical thymic tumor in MN1-TEL–expressing mice. (Middle panel) H-E staining of a thymic tumor section. (Right) M-G staining of thymic tumor cells. (C) Aggressive organ infiltrations by tumor cells. (Left panel) Typical splenomegaly in mice with tumors. (Middle) H-E staining of a spleen section. (Right) H-E staining of a liver section.